Chief
Sleckman, Barry
Associate Chief
Eby, Charles
Al-Kateb, Hussam
Amarasinghe, Gaya
Amarillo, Ina
Barratt, Michael
Blinder, Morey
Bredemeyer, Andrea
Brown, Sarah
Burnham, Carey-Ann
Calderon, Boris
Chang, Li-Wei
Cottrell, Catherine
Dantas, Gautam
Despotis, George
Dunne, Michael
Edelson, Brian
Faith, Jeremiah
Gordon, Jeffrey
Gronowski, Ann
Grossman, Brenda
Handley, Scott
Jackups, Ronald
Kulkarni, Shashikant
Ladenson, Jack
Leung, Daisy
Lin, Jimmy Cheng-Ho
Lockwood, Christina
McDonald, Sandra
McIntosh, Leslie
Mito, Yoshiko
Mohanakumar, Thalachallour
Mosammaparast, Nima
Nagarajan, Rakesh
Oltz, Eugene
Parikh, Bijal
Payton, Jacqueline
Rey, Federico
Scott, Mitchell
Seibert, Karen
Swamidass, Joshua
Tuggey, Robert
Wang, David
Watson, Mark
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Barry Sleckman, MD, PhD
Conan Professor of Pathology and Immunology
Chief of Division of Laboratory and Genomic Medicine | |  |
Dr. Sleckman joined the LGM Division in 2005 and became the director in 2008. He is also the Co-Medical Director of the Clinical Immunology Laboratory. Dr. Sleckman’s laboratory is focused on understanding the genetic programs that promote normal lymphocyte development and on the cellular responses to and repair of DNA damage. |
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Charles Eby, MD
Professor of Pathology and Immunology
Associate Chief of Divison of Laboratory and Genomic Medicine | |  |
Dr. Eby joined the LGM Division in 1991 and became Associate Chief of the LGM Division in 2011. Dr. Eby is also Director of the Hematology and Hemostasis Laboratories at Barnes-Jewish Hospital. Dr. Eby’s research is in the genetic contribution to variability of warfarin dosing through analysis of SNPs in cytochrome 2C9, VKOR and coagulation factors VII and II genes. Dr. Eby’s laboratory also studies molecular risk factors for venous thromboembolic events and acquired functional iron deficiency in cancer patients receiving recombinant erythropoietin. |
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Hussam Al-Kateb, M.Sc., PhD
Assistant Professor of Pathology and Immunology
Associate Director of the CytoGenomics Laboratory | |  |
Dr. Al-Kateb joined the LGM division in November 2010. He is the Associate Director of the CytoGenomics Laboratory. He did his PhD at The University of Heidelberg, Germany and a fellowship in complex disorders at The Hospital for Sick Children, University of Toronto, Canada as well as fellowships in clinical cytogenetics and clinical molecular genetics at Case Western Reserve University, Ohio. Dr. Al-Kateb research interest has been in the discovery of disease genes for both monogenic and complex disorders and in developing of genomic tests for a variety of diseases. Dr. Al-Kateb is also interested in discovering markers for differential diagnosis, prognosis and management of hematological malignancies. |
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Gaya Amarasinghe, PhD
Assistant Professor of Pathology and Immunology
Assistant Professor of Biochemistry and Molecular Biophysics | |  |
Dr. Gaya Amarasinghe joined the LGM Division as an Assistant Professor of Pathology and Immunology in November 2011. His current research interests include the use of biochemical and structural methods to characterize viral immune evasion strategies and host responses. |
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Ina Amarillo, PhD
Assistant Professor of Pathology and Immunology
Associate Medical Director of Cytogenomics and Molecular Pathology | |  |
Dr. Ina Amarillo joined the Division of Laboratory and Genomic Medicine in 2013. She is an Associate Medical Director of the Cytogenomics and Molecular Pathology Laboratory and an Assistant Professor of Pathology and Immunology. Her clinical and academic interests focus on the genetic and cytogenetic bases of human congenital and acquired disorders, as well as orphan diseases. |
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Morey Blinder, MD
Assistant Professor of Medicine
Assistant Professor of of Pathology and Immunology | |  |
Dr. Blinder joined the LGM Division in 1990. He is the Medical Director of Wohl Hematology Laboratory and an Associate Member of the Siteman Cancer Center. Dr. Blinder’s research interests include the diagnosis and treatment of red blood cell disorders as well as platelet and coagulation abnormalities. His laboratory is developing alternative assays to aid in the management of anticoagulant dosing for patients with thromboembolic disease. |
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Sarah Brown, PhD
Instructor of Pediatrics
Instructor of Pathology and Immunology | |  |
Dr. Sarah Brown joined the LGM division in September 2011 after completing the Clinical Chemistry Fellowship at Washington University. She is the Assistant Medical Director of the Core Laboratory and the Medical Director of Ancillary Services at St. Louis Children’s Hospital. Her research interests are in the area of pediatric pharmacology and toxicology. Sarah is also involved in global health care and laboratory quality initiatives. |
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Carey-Ann Burnham, PhD
Assistant Professor of Pathology and Immunology
Medical Director of Clinical Microbiology | |  |
Dr. Carey-Ann Burnham joined the LGM Division in July 2009. Burnham is an Assistant Professor of Pathology & Immunology and Pediatrics at Washington University, and Medical Director of Clinical Microbiology for Barnes Jewish Hospital. She is the program director for the Washington University Fellowship in Clinical and Public Health Microbiology. Her research interests include transmission and epidemiology of Staphylococcus aureus and Clostridium difficile, MALDI-TOF MS methods for Clinical Microbiology, and antimicrobial resistance. |
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Boris Calderon, MD
Assistant Professor of Pathology and Immunology | |  |
Dr. Calderon joined the LGM division in 2010 after completing the Clinical Chemistry Fellowship program here at Washington University. His research is focused on Type 1 Diabetes, especially in the antigen presenting cells (dendritic cells) that normally inhabit the islets of Langerhans, their migration and the early amplification of the autoimmune cellular response. Dr. Calderon is also actively involved in the Clinical Immunology Laboratory at Washington University. |
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Li-Wei Chang, DSc
Instructor of Pathology and Immunology | |  |
Dr. Chang joined the LGM Division in 2010. His research interests are in the development of computational methods and algorithms for inferring transcriptional and post-transcriptional gene regulatory networks through integration of multiple genomic profiling datasets. |
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Catherine Cottrell, PhD
Assistant Professor of Pathology and Immunology
Associate Director, Cytogenomics and Molecular Pathology | |  |
Dr. Catherine Cottrell joined the LGM Division in 2011. She is the Associate Director of the Cytogenomics and Molecular Pathology Laboratory. Dr. Cottrell’s research has primarily focused on the development of clinical testing strategies for the detection of mutations or copy number alterations in human disease. She has a specific interest in the detection of alterations in prognostically important genes related to the development and/or relapse of hematologic malignancy. She is also interested in the detection of uniparental disomy using single nucleotide polymorphism array based platforms. |
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Gautam Dantas, PhD
Assistant Professor of Pathology and Immunology
Assistant Professor of of Biomedical Engineering | |  |
Dr. Gautam Dantas joined the LGM Division as an Assistant Professor of Pathology and Immunology and a member of the Center for Genome Sciences in August 2009. His research interests lie at the interface of microbial genomics and biochemistry, synthetic biology and structural biology, with a specific focus on understanding microbial reservoirs of antibiotic resistance and in engineering microbial catalysis of plant biomass into value chemicals. |
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George Despotis, MD
Associate Professor of Pathology and Immunology
Associate Professor of Anesthesiology | |  |
Dr. Despotis joined the LGM Division in 1997. He is Chair of the Barnes-Jewish Hospital Transfusion Committee. Dr. Despotis’ research interests are in the validation of point-of-care coagulation and platelet function instruments with respect to accuracy, reproducibility and ability to identify patients at risk for bleeding. His clinical interests reside within blood banking and transfusion medicine. |
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Michael Dunne, PhD
Adjunct Professor of Pathology and Immunology | |  |
Dr. Dunne joined the LGM Division in 2000. He was the Medical Director of Barnes-Jewish Hospital Clinical Microbiology Laboratory and the Director of the Medical and Public Health Microbiology Fellowship until 2011 when he took a position as Executive Director of Research and Development for North America at bioMerieux, Inc. He is responsible for overseeing projects involving the development and clinical trials of diagnostic microbiology systems. Dr. Dunne will remain on faculty as an Adjunct Professor of Pathology and Immunology. |
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Brian Edelson, MD, PhD
Assistant Professor of Pathology and Immunology | |  |
Dr. Edelson joined the LGM Division in 2011. His laboratory is focused on understanding how the innate immune system defends against microbial infection, with a particular interest in the molecular pathways leading to the development of macrophage and dendritic cell subsets. Dr. Edelson completed the Clinical Pathology Residency Training program in 2009. |
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Jeffrey Gordon, MD
Dr. Robert J. Glaser Distinguished University Professor
Professor of Developmental Biology & Professor of Medicine | |  |
Dr. Gordon joined the LGM Division in 2008. His laboratory characterizes the genomic and metabolic foundations of mutually beneficial relationships between gut microbial communities and their human hosts. Dr. Gordon has a long-standing commitment to creating an interdisciplinary training environment for students and postdocs interested in human microbial ecology and metagenomics. Together with colleagues, he is conducting clinical trials with twins living in developing as well as industrialized countries. |
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Ann Gronowski, PhD
Professor of Pathology and Immunology
Co-Medical Director of Clinical Chemistry | |  |
Dr. Gronowski joined the LGM Division in 1998. She is the Co-Medical Director of Clinical Chemistry, Serology and Immunology at Barnes-Jewish Hospital, and Co-Director of the Clinical Chemistry Fellowship program. Dr. Gronowski’s research interests are in the development of diagnostic tests to evaluate medical conditions during pregnancy. |
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Brenda Grossman, MD
Associate Professor of Pathology and Immunology
Medical Director of Transfusion Medicine Services | |  |
Dr. Grossman joined the LGM Division in 2009. She is currently the Medical Director of Transfusion Medicine Services, which includes the blood bank, apheresis center, cryopreservation laboratory and apheresis consult service. Dr. Grossman is also the Director of the Clinical Pathology Residency program and the Blood Banking and Transfusion Medicine Fellowship program. Dr. Grossman’s research is focused on clinical aspects of transfusion medicine, especially as it applies to transplant patients. |
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Scott Handley, PhD
Instructor of Pathology and Immunology | |  |
Dr. Handley joined the LGM Division in 2011. He has a background in microbial pathogenesis in the gut and is currently involved in several projects designed to elucidate how the gut microbiome can influence diseases pathology. Dr. Handley is also the Project Manager of the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (MRCE), which supports research and training programs that contribute to the nation’s biodefense and emerging infectious diseases research agenda. |
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Ronald Jackups, MD, PhD
Assistant Professor of Pathology and Immunology
Assistant Professor of Pediatrics | |  |
Dr. Ron Jackups joined the LGM Division in 2012 as the Assistant Director of the Blood Bank and Hematology Laboratory at Barnes-Jewish Hospital. He also serves as the Director of the Blood Bank and Co-Director of the Core Laboratory at St. Louis Children’s Hospital. Dr. Jackups’ research involves informatics applications to blood banking and hematology including inventory management and education. |
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Shashikant Kulkarni, PhD
Associate Professor of Pathology and Immunology
Associate Professor of Pediatrics
Associate Professor of Genetics
Head of Clinical Genomics of Genomics and Pathology Services | |  |
Dr. Kulkarni joined the LGM Division in 2007. He is the Medical Director of Clinical Cytogenomics and Molecular Pathology. Dr. Kulkarni's principle research interest is to study Chromosomal Structural Variants. His lab uses genome-wide tools for the molecular characterization of these variants associated with human development and cancer. He has clinically validated a "chromosomal- microarray/molecular karyotype" which allows detection of uniparental disomy and copy number changes at kilobase-level, a major Leap forward as compared to the megabase-level resolution for conventional chromosome analysis. He is also the Director of the ABMG Medical Genetics Fellowship program. |
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Jack Ladenson, PhD
Oree M. Carroll and Lillian B. Ladenson Professor of Clinical Chemistry of Professor of Pathology and Immunology and Medicine
Co-Medical Director of Clinical Chemistry | |  |
Dr. Ladenson joined the LGM Division in 1972. He has served in many key positions including Interim Director From 2003-2008. Dr. Ladenson’s laboratory has focused on the development of biomarkers for clinical diagnosis. He developed the quantitative test for CK-MB and the first practical Troponin I assay. His current work involves tests for identifying brain injury such as stroke, Alzheimer's disease, etc. He is also Director of clinical pathology programs for Pathologists Overseas, Inc., an organization dedicated to upgrading clinical diagnostic capability in developing countries. |
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Daisy Leung, PhD
Assistant Professor of Pathology and Immunology
Assistant Professor of Biochemistry and Molecular Biophysics | |  |
Dr. Daisy Leung joined the LGM Division in 2011. Her research interests are in using biochemistry and structural biology to understand regulatory mechanisms of signal transduction pathways at the host-viral interface. |
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Christina Lockwood, PhD
Assistant Professor of Pathology and Immunology
Co-director of Molecular Diagnostics | |  |
Dr. Christina Lockwood joined the LGM division in July 2010. She is the Associate Director of the Molecular Diagnostics Laboratory. Dr. Lockwood's research is focused on the discovery and validation of novel biomarkers of tissue injury. She is investigating the diagnostic utility of specific circulating microRNA molecules as sensitive indicators of neuronal and hepatic injury. |
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Sandra McDonald, MD
Associate Professor of Pathology and Immunology | |  |
Dr. Sandra McDonald joined the LGM Division in 2010. She is Director of Tissue Procurement and Associate Director, Laboratory of Translational Pathology. Dr. McDonald is an anatomic/clinical pathologist. Her interests within the area of biospecimen banking include quality assurance and workflow management, translational medicine, pharmacogenomics, the use of biospecimens to study tumor biology and metastatic potential, and the identification of biomarkers that assist in diagnosis, lesion classification and prognostic assessments. |
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Leslie McIntosh, PhD
Assistant Professor of Pathology and Immunology | |  |
Dr. McIntosh joined the LGM Division in 2010. She received her PhD in public health epidemiology from St. Louis University in 2008. Her research interests include using technology to translate and disseminate health data; for example, developing on-line and computer aided surveys in order to reduce input errors, decreasing the time to collect survey data, and increasing user accessibility of the survey. She is also interested in developing better ways to improve the presentation of data to end-users and in learning new techniques to analyze data, such as conjoint analysis and social network analysis. |
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Yoshiko Mito, PhD
Assistant Professor of Pathology and Immunology
Associate Director of Cytogenomics and Molecular Pathology | |  |
Dr. Yoshiko Mito joined the LGM Division in February 2013. She is an Associate Director of the Cytogenomics and Molecular Pathology Laboratory. Her research has been focused on studying how genetic and epigenetic information are inherited through cell divisions and regulate the cellular functions. Dr. Mito’s research topics include chromosome segregation, genome-wide profiling of histone variants and allele-specific mapping of chromatin regulators. More recently, she has been investigating the role of epigenetic regulation in human diseases, particularly in cancer progression and resistance to therapies. |
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Thalachallour Mohanakumar, PhD
Jacqueline G. and William E. Maritz Professor of Surgery
Medical Director of the Histocompatibility Laboratory | |  |
Dr. Mohanakumar joined the LGM Division in 1987. He is the Medical Director of Histocompatibility and Immunogenetics Laboratory and Director of the Islet Cell Core Facility. Dr. Thalachallour’s research is focused on the role of MHC in transplantation and various disease states, including auto-immunity and cancer. |
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Nima Mosammaparast, MD, PhD
Assistant Professor of Pathology and Immunology | |  |
Dr. Mosammaparast joined the LGM division in 2012. He was a resident in clinical pathology at Brigham and Women's Hospital and did postdoctoral work at Harvard Medical School. His research interests lie at the interface of DNA repair and chromatin biology using biochemical and molecular techniques to understand the mechanisms used by mammalian cells to repair their genomes in the chromatin context. |
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Rakesh Nagarajan, MD, PhD
Associate Professor of Pathology and Immunology
Associate Professor of Genetics | |  |
Dr. Nagarajan joined the LGM Division in 2003. He is Director of the Neuroscience Blueprint Biomedical Informatics Core and Director of the Clinical and Translational Science Award Biomedical Informatics Program. Dr. Nagarajan’s laboratory focuses on clinical and biomedical informatics research; development of software applications, which will simultaneously co-analyze and co-visualize functional genomics datasets, gene annotation, and clinicopathological data; and utilization of these heuristic algorithms in order to identify potential diagnostic markers and putative therapeutic targets. |
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Eugene Oltz, PhD
Professor of Pathology and Immunology | |  |
Dr. Eugene Oltz joined the LGM Division in 2009. His laboratory is focused on the biology of chromatin and how modifications in chromatin can contribute to cellular transformation. Dr. Oltz’s lab has been a leader in our understanding of how specific histone modifications are generated and how they can regulate gene transcriptions and programmed gene rearrangements. |
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Bijal Parikh, MD, PhD
Instructor of Pathology and Immunology | |  |
Dr. Bijal Parikh entered the Clinical Pathology Residency program in 2007 after receiving MD and PhD degrees from Robert Wood Johnson Medical School/Rutgers University in Piscataway New Jersey. Originally from New Jersey, he is currently focusing his clinical interests in the Molecular Diagnostics Laboratory. Dr. Parikh’s current research involves investigating virus-host interactions in the laboratory of Dr. Wayne Yokoyama. |
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Jacqueline Payton, MD, PhD
Assistant Professor of Pathology and Immunology
Co-director of Molecular Diagnostics | |  |
Dr. Payton joined the LGM Division in 2008. She is the Medical Director of Molecular Diagnostics and Associate Director for Bioinformatics. Dr. Payton’s research interests are in the development of genomic and epigenomic tests applicable to a wide variety of diseases. She completed Washington University School of Medicine’s Clinical Pathology Residency program where she served as Chief Resident. |
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Federico Rey, PhD
Instructor of Pathology and Immunology | |  |
Dr. Rey joined the LGM Division in 2011. He received his PhD in microbiology from the University of Iowa in 2007. Federico studies how metabolic interactions among human gut microbes impact host physiology. |
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Mitchell Scott, PhD
Professor of Pathology and Immunology
Co-Medical Director of Clinical Chemistry | |  |
Dr. Scott joined the LGM Division in 1987. He is Co-Director of the Clinical Chemistry Fellowship program and Co-Medical Director of the Clinical Chemistry Laboratory. In addition, Dr. Scott is Director of LGM Medical Student Education. Dr. Scott’s research interests focus on clinical chemistry test development in the areas of electrolytes and blood gas evaluation, and in the in area of diagnostic immunoassays. |
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Karen Seibert, PhD
Professor of Pathology and Immunology
Professor of Genetics | |  |
Dr. Karen Seibert is currently Professor of Pathology and Immunology at Washington University School of Medicine. Her work is focused on identifying clinical and translational research programs that have significant potential to lead to improvements in diagnosis or treatment of disease. Previously, Dr. Seibert spent nearly twenty years in the pharmaceutical industry, most recently as Vice President of Research for Pfizer at the St. Louis Laboratories. Her responsibilities included the management of research programs at multiple stages, spanning early new target identification to defining clinical proof of concept as it relates to multiple patient populations. While at Pfizer, Dr. Seibert collaborated with leaders at Washington University to renew the long-standing Biomedical Agreement between the two institutions. She continues as a leader of the collaboration's Joint Steering Committee. |
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Joshua Swamidass, MD, PhD
Assistant Professor of Pathology and Immunology
Assistant Professor of of Biomedical Engineering | |  |
Dr. Swamidass joined the LGM Division in 2009 as a Laboratory Medicine resident and then as an instructor in 2010. Combining math, chemistry, and medicine, Dr. Swamidass' group is focused on designing and applying new computational methods to discover new medicines and improve patient care. |
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Robert Tuggey, PhD
Instructor of Pathology and Immunology | |  |
Dr. Robert Tuggey joined the LGM Division in 2007. After directing clinical labs for many years, he served as a volunteer for one year to improve labs in Bhutan. Working with Dr. Jack Ladenson and Pathologist Overseas, he successfully implemented the first laboratory information system in Jigme Dorji Wangchuk National Reference Hospital. After returning from Bhutan, he joined the faculty in the LGM Division. In cooperation with Pathologist Overseas, the Quality Assurance Training and Monitoring project has expanded to labs in Eritrea, Uganda, and Senegal. |
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David Wang, PhD
Associate Professor of Molecular Microbiology
Associate Professor of Pathology and Immunology | |  |
Dr. Wang joined the LGM Division in 2004. Dr. Wang is one of the Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease. His laboratory focuses on identifying and characterizing novel viruses responsible for human diseases. To this end, they integrate a variety of experimental methodologies that cross many disciplines including molecular biology, virology, genomics, epidemiology and bioinformatics. |
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Mark Watson, MD, PhD
Associate Professor of Pathology and Immunology
Director of Tissue Procurement and Multiplexed Gene Analysis Laboratories | |  |
Dr. Watson joined the LGM Division in 1996. He is Director of the Tissue Procurement Core Facility and Multiplexed Gene Analysis Core Facility at the Siteman Cancer Center, Director of the Central Specimen Bank at the American College of Surgeons Oncology Group and Director of the Laboratory for Clinical Genomics. Dr. Watson’s laboratory is focused on the development and translation of molecular diagnostic tests for a variety of genetic diseases and cancer. |
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