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Research > Faculty By Research Interest > Louis Dehner, MD

Professor, Pathology and Immunology
Professor, Pathology in Pediatrics
3rd Floor, Peters Building
Office: (314) 362-0150
E-mail: dehner@wustl.edu

Research

My scholarly pursuit principally has focused upon neoplasia in childhood, in particular those tumors that have been morphologically characterized as "small blue cell tumors." At one level, I am interested in those variable features of the neoplasms which may influence the clinical outcome. In addition to the clinicopathologic aspects, we have been involved in the refinement of the phenotypic characterization of these tumors through the application of immunohistochemical techniques. Presently, we are engaged in an analysis of primitive neuroectodermal tumors to determine whether ploidy analysis is valuable in the prognostic assessment of these neoplasms. There is evidence that aneuploidy in "classic" neuroblastoma is a marker of favorable prognosis. Nonclassic neuroectodermal tumors and medulloblastoma are the tumors presently under investigation.

Since we are the recipient of extremely unusual tumors of childhood, the files constitute a rich source of archival material to delineate the clinical and pathologic features of these neoplasms. Over the years, we have had the opportunity to define such neoplasms as the embryonal sarcoma of the liver, fetal rhabdomyoma, so-called Askin's tumors and, most recently, the pleuropulmonary blastoma.

I am especially eager to interact with those pathology residents who are considering a career in academic surgical pathology. In this division, we have a core of individuals who can assist the aspiring academic surgical pathologist to develop an idea or hypothesis and answer questions with a variety of techniques ranging from histopathologic analysis to flow cytometry and tissue marker studies.

Clinical Interest

Anatomic and Molecular Pathology - Soft Tissue and Bone Neoplasms
Anatomic and Molecular Pathology - Electron Microscopy
Anatomic and Molecular Pathology - Dermatopathology
Anatomic and Molecular Pathology - Pediatric Pathology

Selected Publications

Luo JJ, Baksh FK, Pfeifer JD, Eastman JT, Beyer FC, Dehner LP.. Abdominal mucinous cystic neoplasm in a male child.. Pediatr Dev Pathol 11:46-49, 2008 Abstract

Hill DA, Jarzembowski JA, Priest JR, Williams G, Schoettler P, Dehner LP.. Type I pleuropulmonary blastoma: Pathology and biopsy study of 51 cases from the Internationa Pleuropulmonary Blastoma Registry. Am J Surg Pathol 32:282-295., 2008 Abstract

Luo J, Melnick S, Rossi A, Burke R, Pfeifer J, Dehner LP.. Primary cardiac alveolar soft part sarcoma. A report of the first observed case with molecular diagnostics corroboration.. Pediatr Dev Pathol 11:142-147, 2008 Abstract

Reck SJ, Xia L, Dehner LP, Reising CA.. Glandular congenital lymphadenoma.. Pediatr Dermatol 24:547-550, 2007 Abstract

Dehner LP, Yin H, Yost R.. Median Raphe cyst in the scrotum after orchiopexy.. Int J Urol 14:573-574, 2007 Abstract

Hameed O, Dehner LP.. Malignant teratoma vs carcinoma with teratomatous elements, rather than metaplastic carcinoma. Breast 16:5-6, 2007 Abstract

Skapek SX, Ferguson WS, Granowetter L, Devidas M, Perez-Atayde AR, Dehner LP, Hoffer FA, Speights R, Gebhardt MC, Dahl GV, Grier HE; Pediatric Oncology Group.. Vinblastine and methotrexate for desmoids fibromatosis in children: results of a Pediatric Oncology Group Phase II Trial.. J Clin Oncol 25:501-506, 2007 Abstract

Sanati S, Lu DW, Schmidt E, Perry A, Dehner LP, Pfeifer JD.. Cytologic diagnosis of Ewing sarcoma/peripheral neuroectodermal tumor with paried prospective molecular genetic analysis.. Cancer 111:192-199, 2007 Abstract

Kirby PA, Sato Y, Tannous R, Dehner LP.. Calcifying fibrous pseudotumor of the myocardium. Pediatr Dev Pathol 9:384-387, 2006 Abstract

Wild PJ, Giedl J, Stoehr R, Junker K, Boehm S, Van Oers JM, Zwarthoff EC, Blaszyk H, Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI, Hartman A.. Urothelial neoplasms in individuals younger than 20 years show very few genetic alterations and have a favourable clinical outcome.. Verh Dtsch Ges Pathol 90:253-263, 2006 Abstract

Priest JR, McDermott MB, Bhatia S, Watterson J, Manivel JC, Dehner LP.. Pleuropulmonary blastoma. A clincopathologic study of 50 cases.. Cancer 80:147-161, 1997 Abstract

Dehner LP, Watterson J, Priest J.. Pleuropulmonary blastoma.. In: Perspect. Pediatr Pathol, Askin FB, Langston C, Rosenberg HS, and Bernstein J, eds., Basel, Karger, 18:214-226, 1995

Dehner LP.. Pleuropulmonary blastoma is the pulmonary blastoma of childhood.. Semin Diagn Pathol 11:144-151, 1994 Abstract