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Faculty > Faculty Alphabetical > Anjum Hassan, MD

Assistant Professor, Pathology and Immunology
Peters Building, 3rd Floor, Room 300K
Office: (314) 747-1120
E-mail: ahassan@path.wustl.edu
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Research

My research involves work on small lymphocytic leukemia, a very prevalent disease among Western countries. The project eventually involves setting up the system for direct sequencing of immunoglobulin genes from paraffin sections. I am in the process of learning the relevant techniques and applying it to a collection of small lymphocytic lymphoma cases available in our archival material. Our focus will include identification of those signal transduction pathways which appear most likely to be affected by over-expression ZAP-70 in B cells. We have looked into commercially available antibodies, as well as some antibodies which are available locally for this purpose. We also plan to work on p53 status in SLL in order to correlate if progressive disease accumulates those mutations in chronologically selected specimens on same patients.

Another focus of my research involves studying the pathogenesis of Multiple Myeloma. This involves a pilot study to optimize PCR detection of ras mutations in archival material in the Department of Pathology and Immunology and correlating that with t(4;14) and t(11;14) in established myeloma cases. This will also lay the grounds for a test available for evaluation of clinical specimens.

Service to the University

2006 - PresentAssistant Director, Fluorescent in-situ Hybridization Lab in Anatomic Pathology
2005 - 2008Second year Adrenal pathology course
2005 - PresentSecond year medical student Hematopathology Lab curriculum

Diagnostic Expertise

Board certified in Anatomic and Clinical Pathology ; Board certified in Hematopathology

Clinical Interest

Anatomic and Molecular Pathology - Hematopathology

Selected Publications

Zhao, XF, Hassan A, Perry A, Ning Y, Stass SA, Dehner LP. B-cell lymphomas with atypical morphology and c-myc rearrangements. Int J clin exp pathol 1(1): 65-74,2008 ., 2008

Hassan A, Kreisel F, Lewis J, Gardner L, El-Mofty S.. Plasmablastic lymphoma of head and neck: report of two new cases and correlation with c-myc and IgVH gene mutation status. Head and Neck pathology, Oct 2007, available on line. DOI 10.1007/s12105-007-00060-5., 2007

Kaleem Z, Hassan A.. Pathologic Quiz Case: Multiple lytic bone lesions in an 85-year-old man.. Arch Pathol Lab Med 129:e148-150, 2005 Abstract

Hassan A, Yerian LM, Kuan SF, Xiao SY, Hart J, Wang HL. Immunohistochemical evaluation of adenomatous polyposis coli, beta-catenin, c-Myc, cyclin D1, p53, and retinoblastoma protein expression in syndromic and sporadic fundic gland polyps.. Hum Pathol 35:328-334, 2004 Abstract

Kaleem Z, Hassan A, Pathan MH, White G.. Flow Cytometric Evaluation of Posttransplant B-Cell Lymphoproliferative Disorders.. Arch Pathol Lab Med 128:181-186, 2004 Abstract

Hassan A, Bennet A, Bhalla S, Ylagan LR, Mutch D, Dehner LP. Paraganglioma of the vagina: Ultrastructural and immunohistochemical study.. Int J Gynecol Pathol, 22:404-406, 2003 Abstract

Liapis H, Hassan A. Idiopathic light chain deposition disease without clinical evidence of Multiple Myeloma. Int Urol Nephrol 35:579-580, 595-596, 2003 Abstract

Coopersmith CA, Lowell JA, Hassan A, Howard TK. Hepatocellular carcinoma in a patient with focal nodular hyperplasia.. Arch Pathol Lab Med 128:181-186, 2002